Star Trek is an American media franchise, consisting of numerous television shows and movies. It stars the crew of the starship USS Enterprise, as they travel the stars.

There is some debate on On Cinema as to which movie in the original series of films takes place in San Francisco. Host Tim Heidecker has stated his position that he believes that Star Trek IV: The Voyage Home is single film in the series primarily set in San Francisco, while his guest Gregg Turkington insists that only Star Trek II: The Wrath of Khan takes place in the city.

• Podcast Episode 8: "Star Trek II: The Wrath of Khan" focuses on a retrospective of Star Trek II: The Wrath of Khan. Gregg off-handedly mentions it takes place in San Francisco, in modern times, which Tim disputes. The rest of the episode becomes a discussion as to if Gregg is thinking of Star Trek IV: The Voyage Home.